Unlike HPLC, which relies on the elution of analytes, CCC offers numerous methods to "get the analyte out of the column". E.g., have you ever tried to extrude an HPLC column? While this would clearly be destructive to the column, one will still have to recover the analyte from the solid stationary phase.

No problem in CCC: the column can be extruded at any time, since the stationary phase is liquid. Extrusion is one of the major benefits of working with a liquid stationary phase. One way of getting high-resolution separation through extrusion mechanisms is elution-extrusion CCC (EECCC). More can be found in Berthod, A.; Friesen, J. B.; Inui, T.; Pauli, G. F. Elution-extrusion countercurrent chromatography: theory and concepts in metabolic analysis. Anal. Chem. 2007, 79, 3371-3382.

Anybody out there with EECCC experience on FCPC machines?