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Written by The Clever Chromatographer   
Wednesday, 04 July 2012 17:25

A recent article in Phytochemical Analysis entitled “Preparative isolation, fast centrifugal partition chromatography purification and biological activity of cajaflavanone from Derris ferruginea stems” describes the use of FCPC to isolate a single bioactive compound from a Vietnamese plant. In addition to explaining the method of isolation, the article goes on to demonstrate the biological activity of cajaflavanone in antifungal, antibacterial, antileishmanial, cytotoxicity, antioxidant (DPPH and ORAC), advanced glycation endproduct (AGE) accumulation, and antiplasmodium assays. In particular, the AGE assay results seemed interesting. cajaflavoneThe preparation by FCPC was compared to a column chromatography protocol starting with a silica gel column and followed by LH-20. The resulting compounds were of nearly equal purity by that is where the similarity stopped. Liquid chromatography required 40 times more time and 36 times more solvent. Incredibly, the % yield was 10 times higher with FCPC than with liquid chromatography!

Last Updated on Wednesday, 04 July 2012 17:32
 
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Written by Administrator   
Monday, 06 April 2009 06:56

Dear User:

This site was launched to provide a networking opportunity for all scientists and practitioners of counter-current chromatography, as well as those interested in modern liquid-liquid separation technology.

While the resources on this website are in the process of being built, this menu provides links to external sites that offer significant information about CCC technology. Eventually, INCCC.NET intends to serve as a comprehensive, global resource for this purpose. While these activities are ongoing, "INCCC resources" are supplemented with information from external links.
 

The INCCC webteam 

Last Updated on Monday, 06 April 2009 15:40